The Science MetaDeq Diagnostics

The Science

Normal Liver Health Involves Multiple Cell Types, Including Monocytes

Liver-Specific Monocytes Released into Blood

Liver Health in the Blood

It is hypothesized that as MASH progresses in the liver, resident Kupffer Cells KCs) are replaced by monocyte-derived macrophages (MoMFs)
MoMFs are reprogrammed / repolarized and re-enter the circulatory system
Specific monocyte biomarkers in the blood reflect the state of liver health

Source: https://mayoclinic.org/NASH/Expertise

Liver-specific Monocytes Shed into the Blood Stream

Metadeq Diagnostics identified three biomarkers in blood monocytes that are surrogates for liver health

Levels of these biomarkers in the blood correlated with the stages of liver decline as a result of MASH and/or fibrosis

The identified biomarkers for MASH diagnosis are not a measure of fat accumulation alone, but principally of liver inflammation and MASH activity

Validation of Identified Biomarkers

Potentially Best-in-Class for Predicting
MASH Diagnosis

Source: Science, 1988, 240: 1285-93

Liquid biopsy tests are gaining traction in the diagnostics industry as a viable alternative to traditional invasive procedures
Three non-specific diagnostic tests have been approved by the FDA: Siemens’ ELF Test (a 3 biomarker blood assay), EchoSens’ FibroScan (an ultrasound device), and Perspectum Diagnostics’ LiverMultiScan (an injectable imaging marker)
Other available NITs include: NIS4, OWLiver, FibroSURE, FIB-4, AGILE3+, LIVERFASt, and many others, but in large scale, multi-year studies such as LITMUS and NIMBLE, no biomarker has shown >0.9 AUROC